Dietary Restriction Alters Retinol and Retinol-Binding Protein Metabolism in Aging Rats
نویسندگان
چکیده
منابع مشابه
Regulation of retinol‐binding protein 4 and retinol metabolism in fatty liver disease
Vitamin A refers to a spectrum of retinoid compounds (retinol, retinoic acid, and retinaldehyde) with important functions in different tissues, including the retina and skin. Retinoids regulate metabolic pathways through binding to two nuclear hormone receptors: retinoic acid receptor and retinoid X receptor. In humans, approximately 80% of the body reservoir of vitamin A is stored in the liver...
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Vitamin A (retinol) is required to maintain immunity and epithelial turnover and is a key micronutrient needed for combating infection. Vitamin A actions on the immune system are diverse and cannot be accounted for by a single effect or mechanism. The actions of retinol in maintaining gut integrity in humans and immunoglobulin levels in mice was investigated. For 30 children, performance on the...
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In hemodialysis (HD) patients, serum prealbumin (TBPA) is correlated to nutritional status and outcome despite usually elevated serum levels. The purpose of this work was to study the role of TBPA-retinol-binding-protein (RBP)-retinol complex changes in the elevation of serum TBPA in HD patients. Serum TBPA, RBP, and retinol were measured in 30 otherwise healthy HD patients (15 men, 15 women) a...
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I . The plasma concentration of retinol-binding holoprotein (holo-RBP) in rats given retinol-sufficient diets containing 50 g soya-bean protein/kg was 90 yo of the concentration found in controls given zoo g soya-bean protein/kg, whereas in rats given 50 g rice protein/kg it was only 68 % of the control value. Plasma albumin concentrations in the low-protein groups were lower by 20-25 %. 2. The...
متن کاملBinding of retinol induces changes in rat cellular retinol-binding protein II conformation and backbone dynamics.
The structure and backbone dynamics of rat holo cellular retinol-binding protein II (holo-CRBP II) in solution has been determined by multidimensional NMR. The final structure ensemble was based on 3980 distance and 30 dihedral angle restraints, and was calculated using metric matrix distance geometry with pairwise Gaussian metrization followed by simulated annealing. The average RMS deviation ...
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ژورنال
عنوان ژورنال: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
سال: 1999
ISSN: 1079-5006,1758-535X
DOI: 10.1093/gerona/54.9.b384